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KMID : 1001020110090020068
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Journal of Urologic Oncology
2011 Volume.9 No. 2 p.68 ~ p.75
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Expression of Heat Shock Protein 27 and Cellular FLICE-like Inhibitory Protein of Urothelial Carcinoma of the Upper Tract
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Cho Jeong-Man
Cho Hee-Joo
Moon Kyong-Tae
Min Dong-Suk
Kim Eun-Kyung
Kim Duk-Yoon
Park Jae-Shin
Yoo Tag-Keun
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Abstract
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Purpose: We investigated the expressions of Heat shock protein 27(HSP27) and Cellular FLICE-like inhibitory protein(c-FLIP) with urothelial carcinoma of the upper tract.
Materials and Methods: The expressions of HSP27 and c-FLIP were quantified immunohistochemically form sixty one patients who underwent nephroureterectomy for urothelial carcinoma of the upper tract and 10 patient’s normal ureteral tissues who underwent nephrectomy. The overall percentage of cancer cells showing staining(0% to 100%) was indicated by visual scoring. Specimens were graded from 0 to +3 intensity representing the range of staining area, for which below 1% is 0 grade, 1-10% is+1 grade, 10-50% is +2 grade, over 50% is +3 grade.
Results: HSP27 positive reaction was seen in 10 of 10 cases(100%) with a normal ureter, 59 of 61 cases(96.7%) with urothelial carcinoma of the upper tract. The mean HSP27 reaction scores were 2.67 with low grade, 2.27 with high grade(p=0.045). HSP27 expression was not statistically significant according to stage and lymph node metastasis. c-FLIP positive reaction was seen in 0 of 10 cases(0%) with normal ureter, 57 of 61 cases(93.4%) with urothelial carcinoma of the upper tract. c-FLIP expression was not statistically significant according to grade, stage and lymph node metastasis.
Conslusions: This study suggests that the expression of HSP27 is reduced and the expression of c-FLIP is increased in patients with urothelial carcinoma of the upper tract. If these data are confirmed, HSP27 and c-FLIP may be usable as prognostic marker of urothelial carcinoma of the upper tract.
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KEYWORD
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Urothelial carcinoma, Heat shock protein 27, Cellular FLICE-like inhibitory protein
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